Friday, September 27, 2013

V. Le Démonstrateur




After a cursory search of Stencil’s alpha index—The 1963 debut of V.,
Where you are a primordial inclusion—A furanose ring, five-carbon ribose,
Detached from what originally surrounded it—Oxygen on a fretted diamond’s
Apex—RNA’s single-strand enduring the crossing of that wilderness of Hadean
Eon when there were two folded protein domains—Up to our episode of atomic
Coordinates pinning large and small ribosomal subunits, where the factors bind

Gene and catalyst in a headless contest until the loosed beast of venery binds
Black Diamond Bay and Karl Baedeker’s Egypt—We ascertain from Pynchon’s V.
Both the lava shield and the acid bath as sites for primordial RNA—Atomic
CG modeling yields to a single-stranded nucleic acid with four-carbon threose—Ribose
Drops in a later assembled hairpin looming over the quiet sweep of Black Diamond
Bay—There, a violinist chucks her violin for a mute symphony in a Hadean

World 40 years later; with Lolita’s duplicity, Heyst as a Soviet tyrant—Hadean
Abduction occurs in this sequence—RNA hydrogen-bonds itself; its template strand binds
AUG, awaiting the terminal mismatches of a triad, and object of every action; unlike diamonds,
Which scatter infinitely through its networks—Knowing your signal five-by-five, V.
Your uncontrollable elements, where incunabula of your calcium reserve extends atomic
Predictions—At the five prime untranslated region (5' UTR), small nuclear ribonucleoproteins

Splice all the implied epithets of your genes’ expression—Except for lariats, a ribosomal
Complex decrypts the folded strands of consciousness—Proteins charge this Hadean
Tight-rope walk—A destined name heard over indolent rope-skipping, where desired atomic
Constellations are, rather, immovable knots—Aminoacyl tRNA synthetase binds
Translating ribosomes; each anticodon specifies which protein—On that beam, a diamond’s
Fire catches its complement—With bewildering ease, the optics in a portraitist’s cramped room, V.—

Assumed into the fabric of any of a thousand Great Paintings—Nothing more than V.'s
Comb—Optical proof she existed in a novel, or it fell from a lacemaker’s hair—Ribonucleic
Acid’s single floss gathers premises, folds into tertiary structure, and the veins of diamond
In volcanic pipes—Unless we accept receding deeper into pluton, invisible, there is a Hades
Figure taxiing commodities of the dead, who flints our consciousness into atomic
Energy leaps—Functional protein is recovered; its ends charged at biological pH—Ribose

Aptly stacks the DNA double helix with a pucker, and the 2'-OH of the ribose
Sugar mediates RNA binding to the adenine-thymine minor groove—Chapter V.
Calypso frees Odysseus, bereft her single, fallen-off transcript—Reversing the atom,
Stencil pursues V., or entertain the possibility of letting one’s thoughts go empty—Ribonucleic
Acid’s distinctive feature is the compulsion to replicate; it is degraded easily, beyond Hadean
Sulfur pits, or nuclear pores—Greater and less than we can imagine, V., is Black Diamond

Bay’s capacity—For a Soviet ambassador, a desperate Greek—Ribonucleic acids are a diamond
Precious, biological machine that two, original RNA molecules reprise as spurs of other atoms
Exoteric and penetrating as you, V., where this Hadean heat of diverse life forms—A singular creation.

2 comments:

Σφιγξ said...

I have a patient with beta-thalassemia requiring blood exchanges and hydroxyurea, an inducer of the production of hemoglobin f, which is the predominant form in fetal hemoglobin. The Hbf is more functional and clots less in vasculopathies in these patients and those with sickle cell anemia (SCA).


https://pubmed.ncbi.nlm.nih.gov/8562958/#:~:text=hemoglobin%20E%20disease-,Hydroxyurea%20increases%20hemoglobin%20F%20levels%20and%20improves%20the%20effectiveness%20of,(3)%3A887%2D92.

This article suggests the use of hydroxyurea for Covid coagulopathies. The mechanism in general is summarized:

"Hydroxyurea is a cytotoxic drug which was initially prescribed for malignancies. As the main mechanism of action of hydroxyurea is inhibition of rNDP enzyme, thus arresting cells at G1 or S phase of the cell cycle, bone marrow suppression is commonly associated with its treatment. Pancytopenia, leukopenia, neutropenia and thrombocytopenia are reported in numerous clinical trials [21, 37,38,39,40].

Cellular and molecular effects of hydroxyurea
Hydroxyurea induces stress erythropoiesis by inhibiting the synthesis of DNA, thus giving a selective advantage to the expansion of the F cell population over the rapidly dividing HbA producing erythroid progenitors (Fig. 1). In addition, downregulation of genes responsible for chromosome organisation, translation and ribosome assembly has been observed in early reticulocytes following hydroxyurea treatment [41]."

https://ojrd.biomedcentral.com/articles/10.1186/s13023-021-01757-w#:~:text=As%20the%20main%20mechanism%20of,commonly%20associated%20with%20its%20treatment.

Σφιγξ said...

This patient had his spleen removed, and thus lost his humoral immunity together with low white counts.