Detached from what originally
surrounded it—Oxygen on a fretted diamond’s
Apex—RNA’s single-strand enduring
the crossing of that wilderness of Hadean
Eon when there were two folded
protein domains—Up to our episode of atomic
Coordinates pinning large and small
ribosomal
subunits,
where the factors bind
Black Diamond Bay and Karl
Baedeker’s
Egypt—We
ascertain from Pynchon’s V.
Both the lava shield and the acid
bath as sites for primordial RNA—Atomic
CG modeling yields to a
single-stranded nucleic acid with four-carbon
threose—Ribose
Bay—There, a
violinist
chucks her violin for a mute symphony in a Hadean
World 40 years later; with Lolita’s duplicity, Heyst as a Soviet
tyrant—Hadean
Abduction occurs in this sequence—
RNA hydrogen-bonds
itself; its template strand binds
AUG, awaiting the terminal
mismatches
of a triad, and object of every action; unlike diamonds,
Which scatter infinitely through
its networks—Knowing your signal
five-by-five,
V.
Your uncontrollable elements, where
incunabula of
your calcium
reserve
extends atomic
Splice
all the implied epithets of your genes’ expression—Except for
lariats, a ribosomal
Complex decrypts the folded strands
of consciousness—Proteins charge this Hadean
Tight-rope walk—A destined name
heard over indolent rope-skipping, where desired
atomic
Constellations are, rather, immovable knots—
Aminoacyl
tRNA synthetase binds
Translating ribosomes; each
anticodon specifies which protein—On that beam, a diamond’s
Fire catches its complement—With
bewildering ease, the
optics
in a portraitist’s cramped room, V.—
Acid’s single floss gathers
premises, folds into tertiary structure, and the veins of diamond
In volcanic
pipes—Unless
we accept receding deeper into
pluton, invisible,
there is a Hades
Figure taxiing commodities of the
dead, who flints our consciousness into atomic
Energy leaps—Functional protein is
recovered; its ends charged at
biological pH—Ribose
Aptly stacks the DNA double helix with a
pucker,
and the 2'-OH of the ribose
Sugar mediates RNA binding to the adenine-thymine minor groove—
Chapter
V.
Calypso frees Odysseus, bereft her
single,
fallen-off
transcript—Reversing the
atom,
Stencil pursues V., or entertain the possibility of letting one’s thoughts go
empty—Ribonucleic
Acid’s distinctive feature is the compulsion to replicate; it is degraded
easily, beyond Hadean
Sulfur
pits, or nuclear
pores—Greater
and less than we can imagine, V., is Black Diamond
Bay’s capacity—For a Soviet
ambassador,
a desperate Greek—Ribonucleic acids are a diamond
Precious, biological machine that two, original RNA molecules reprise as spurs
of other
atoms—
Exoteric and penetrating as you,
V., where this Hadean heat of diverse life forms—A singular creation.
2 comments:
I have a patient with beta-thalassemia requiring blood exchanges and hydroxyurea, an inducer of the production of hemoglobin f, which is the predominant form in fetal hemoglobin. The Hbf is more functional and clots less in vasculopathies in these patients and those with sickle cell anemia (SCA).
https://pubmed.ncbi.nlm.nih.gov/8562958/#:~:text=hemoglobin%20E%20disease-,Hydroxyurea%20increases%20hemoglobin%20F%20levels%20and%20improves%20the%20effectiveness%20of,(3)%3A887%2D92.
This article suggests the use of hydroxyurea for Covid coagulopathies. The mechanism in general is summarized:
"Hydroxyurea is a cytotoxic drug which was initially prescribed for malignancies. As the main mechanism of action of hydroxyurea is inhibition of rNDP enzyme, thus arresting cells at G1 or S phase of the cell cycle, bone marrow suppression is commonly associated with its treatment. Pancytopenia, leukopenia, neutropenia and thrombocytopenia are reported in numerous clinical trials [21, 37,38,39,40].
Cellular and molecular effects of hydroxyurea
Hydroxyurea induces stress erythropoiesis by inhibiting the synthesis of DNA, thus giving a selective advantage to the expansion of the F cell population over the rapidly dividing HbA producing erythroid progenitors (Fig. 1). In addition, downregulation of genes responsible for chromosome organisation, translation and ribosome assembly has been observed in early reticulocytes following hydroxyurea treatment [41]."
https://ojrd.biomedcentral.com/articles/10.1186/s13023-021-01757-w#:~:text=As%20the%20main%20mechanism%20of,commonly%20associated%20with%20its%20treatment.
This patient had his spleen removed, and thus lost his humoral immunity together with low white counts.
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